Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1928867..1929643 Replicon chromosome
Accession NZ_CP097571
Organism Staphylococcus aureus strain V40

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag M8789_RS09320 Protein ID WP_000031108.1
Coordinates 1928867..1929019 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag M8789_RS09325 Protein ID WP_001251219.1
Coordinates 1929044..1929643 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8789_RS09305 (1924871) 1924871..1925692 + 822 WP_000669377.1 RluA family pseudouridine synthase -
M8789_RS09310 (1926142) 1926142..1927527 - 1386 WP_250164276.1 class II fumarate hydratase -
M8789_RS09315 (1927723) 1927723..1928118 - 396 WP_000901023.1 hypothetical protein -
M8789_RS09320 (1928867) 1928867..1929019 - 153 WP_000031108.1 SAS053 family protein Toxin
M8789_RS09325 (1929044) 1929044..1929643 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
M8789_RS09330 (1929802) 1929802..1930272 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8789_RS09335 (1930277) 1930277..1931404 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
M8789_RS09340 (1931555) 1931555..1932277 - 723 WP_250164475.1 amino acid ABC transporter ATP-binding protein -
M8789_RS09345 (1932270) 1932270..1933727 - 1458 WP_000649902.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T245594 WP_000031108.1 NZ_CP097571:c1929019-1928867 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT245594 WP_001251219.1 NZ_CP097571:c1929643-1929044 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References