Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 531276..531769 Replicon chromosome
Accession NZ_CP097561
Organism Ligilactobacillus murinus ASF361

Toxin (Protein)


Gene name relE Uniprot ID A0A829DKF8
Locus tag C822_RS02905 Protein ID WP_004047837.1
Coordinates 531494..531769 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829DFA4
Locus tag C822_RS02900 Protein ID WP_004047835.1
Coordinates 531276..531497 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C822_RS02890 (C822_000586) 528379..529764 - 1386 WP_004047832.1 L,D-transpeptidase family protein -
C822_RS02895 (C822_000587) 529921..531093 + 1173 WP_004047661.1 IS256 family transposase -
C822_RS02900 (C822_000588) 531276..531497 + 222 WP_004047835.1 DUF6290 family protein Antitoxin
C822_RS02905 (C822_000589) 531494..531769 + 276 WP_004047837.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C822_RS02910 532032..532763 - 732 Protein_581 5'-nucleotidase, lipoprotein e(P4) family -
C822_RS02915 (C822_000592) 532964..533257 + 294 WP_004047845.1 hypothetical protein -
C822_RS02920 (C822_000593) 533352..533954 + 603 WP_039936077.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
C822_RS02925 (C822_000594) 534019..534546 + 528 WP_004049359.1 helix-turn-helix domain-containing protein -
C822_RS02930 (C822_000595) 534531..535406 + 876 WP_286011503.1 IS3 family transposase -
C822_RS02935 (C822_000596) 535503..536375 + 873 WP_004047853.1 aldose 1-epimerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 488781..558846 70065
- flank IS/Tn - - 529921..531093 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-88)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10984.72 Da        Isoelectric Point: 10.2588

>T245588 WP_004047837.1 NZ_CP097561:531494-531769 [Ligilactobacillus murinus ASF361]
MKEYHVEYSKRAQKQIKKLDRQIQRLLFAWIDKNLEGVSDPRIHGKGLTGNHAREWRYRIGDYRLICDIQDDIMIILALE
FGHRRSVYNKK

Download         Length: 276 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8540.55 Da        Isoelectric Point: 4.3566

>AT245588 WP_004047835.1 NZ_CP097561:531276-531497 [Ligilactobacillus murinus ASF361]
MATISIRLNQQEEELFKGYAELTGENLSTLFKEALKKSIDDEYDLQVYKEAYKEYQQDPVTISHADFKKELGF

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829DKF8

Antitoxin

Source ID Structure
AlphaFold DB A0A829DFA4

References