Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5042659..5043917 Replicon chromosome
Accession NZ_CP097560
Organism Pseudomonas aeruginosa strain C4.2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PAC42_RS24205 Protein ID WP_023109087.1
Coordinates 5042659..5043414 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PAC42_RS24210 Protein ID WP_003086329.1
Coordinates 5043549..5043917 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC42_RS24195 (PAC42_24130) 5037831..5040374 + 2544 WP_003123188.1 acyl-homoserine-lactone acylase QuiP -
PAC42_RS24200 (PAC42_24135) 5040529..5041890 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PAC42_RS24205 (PAC42_24140) 5042659..5043414 - 756 WP_023109087.1 RES family NAD+ phosphorylase Toxin
PAC42_RS24210 (PAC42_24145) 5043549..5043917 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PAC42_RS24215 (PAC42_24150) 5043990..5045276 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PAC42_RS24220 (PAC42_24155) 5045332..5046921 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PAC42_RS24225 (PAC42_24160) 5047000..5047476 + 477 WP_023109088.1 hypothetical protein -
PAC42_RS24230 (PAC42_24165) 5047479..5047754 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28264.40 Da        Isoelectric Point: 7.7294

>T245585 WP_023109087.1 NZ_CP097560:c5043414-5042659 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT245585 WP_003086329.1 NZ_CP097560:c5043917-5043549 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References