Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 4111555..4112776 | Replicon | chromosome |
Accession | NZ_CP097560 | ||
Organism | Pseudomonas aeruginosa strain C4.2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | PAC42_RS19780 | Protein ID | WP_003114949.1 |
Coordinates | 4112198..4112776 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | PAC42_RS19775 | Protein ID | WP_003088112.1 |
Coordinates | 4111555..4112109 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PAC42_RS19750 (PAC42_19695) | 4107123..4107674 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
PAC42_RS19755 (PAC42_19700) | 4107671..4108069 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
PAC42_RS19760 (PAC42_19705) | 4108082..4108405 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
PAC42_RS19765 (PAC42_19710) | 4108736..4109197 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
PAC42_RS19770 (PAC42_19715) | 4109202..4111397 | + | 2196 | WP_268173838.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
PAC42_RS19775 (PAC42_19720) | 4111555..4112109 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
PAC42_RS19780 (PAC42_19725) | 4112198..4112776 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
PAC42_RS19785 (PAC42_19730) | 4112884..4114071 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
PAC42_RS19790 (PAC42_19735) | 4114061..4116232 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
PAC42_RS19795 (PAC42_19740) | 4116222..4117499 | - | 1278 | WP_003122808.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T245584 WP_003114949.1 NZ_CP097560:4112198-4112776 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT245584 WP_003088112.1 NZ_CP097560:4111555-4112109 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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