Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 4111555..4112776 Replicon chromosome
Accession NZ_CP097560
Organism Pseudomonas aeruginosa strain C4.2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PAC42_RS19780 Protein ID WP_003114949.1
Coordinates 4112198..4112776 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PAC42_RS19775 Protein ID WP_003088112.1
Coordinates 4111555..4112109 (+) Length 185 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC42_RS19750 (PAC42_19695) 4107123..4107674 + 552 WP_003102727.1 XRE family transcriptional regulator -
PAC42_RS19755 (PAC42_19700) 4107671..4108069 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PAC42_RS19760 (PAC42_19705) 4108082..4108405 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PAC42_RS19765 (PAC42_19710) 4108736..4109197 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PAC42_RS19770 (PAC42_19715) 4109202..4111397 + 2196 WP_268173838.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PAC42_RS19775 (PAC42_19720) 4111555..4112109 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PAC42_RS19780 (PAC42_19725) 4112198..4112776 + 579 WP_003114949.1 HD domain-containing protein Toxin
PAC42_RS19785 (PAC42_19730) 4112884..4114071 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PAC42_RS19790 (PAC42_19735) 4114061..4116232 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
PAC42_RS19795 (PAC42_19740) 4116222..4117499 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(16-170)

Antitoxin

(14-62)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T245584 WP_003114949.1 NZ_CP097560:4112198-4112776 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp


Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT245584 WP_003088112.1 NZ_CP097560:4111555-4112109 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References