Detailed information of TA system TA245583

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1978157..1979665
• Replicon: chromosome
• Accession: NZ_CP097560
• Organism: Pseudomonas aeruginosa strain C4.2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PAC42_RS09325
• Protein ID: WP_079761040.1
• Coordinates: 1978157..1978744 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PAC42_RS09330
• Protein ID: WP_057388475.1
• Coordinates: 1978811..1979665 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAC42_RS09320 (PAC42_09310)	1974412..1977891	-	3480	WP_058017285.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
PAC42_RS09325 (PAC42_09315)	1978157..1978744	+	588	WP_079761040.1	GNAT family protein	Toxin
PAC42_RS09330 (PAC42_09320)	1978811..1979665	+	855	WP_057388475.1	AraC family transcriptional regulator	Antitoxin
PAC42_RS09335 (PAC42_09325)	1979762..1981927	+	2166	Protein_1852	TonB-dependent receptor family protein	-
PAC42_RS09340 (PAC42_09330)	1982102..1983976	+	1875	WP_033968656.1	MFS transporter	-
PAC42_RS09345 (PAC42_09335)	1984037..1984246	-	210	WP_003091604.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21932.24 Da
• Isoelectric Point: 9.5188

>T245583 WP_079761040.1 NZ_CP097560:1978157-1978744 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRTLPLAVRLGVELV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31881.17 Da
• Isoelectric Point: 7.5295

>AT245583 WP_057388475.1 NZ_CP097560:1978811-1979665 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEVHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Nucleotide

• Length: 855 bp