Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142484..142989 Replicon chromosome
Accession NZ_CP097560
Organism Pseudomonas aeruginosa strain C4.2

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PAC42_RS00660 Protein ID WP_003083773.1
Coordinates 142484..142765 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PAC42_RS00665 Protein ID WP_003083775.1
Coordinates 142762..142989 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC42_RS00635 (PAC42_00635) 137735..139084 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PAC42_RS00640 (PAC42_00640) 139133..139819 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PAC42_RS00645 (PAC42_00645) 139920..140654 + 735 WP_003117208.1 GntR family transcriptional regulator -
PAC42_RS00650 (PAC42_00650) 140834..141244 + 411 WP_003110659.1 aegerolysin family protein -
PAC42_RS00655 (PAC42_00655) 141276..142184 - 909 WP_057386940.1 LysR family transcriptional regulator -
PAC42_RS00660 (PAC42_00660) 142484..142765 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PAC42_RS00665 (PAC42_00665) 142762..142989 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PAC42_RS00670 (PAC42_00670) 143165..143785 - 621 WP_003101226.1 hypothetical protein -
PAC42_RS00675 (PAC42_00675) 143886..144386 + 501 WP_057386938.1 LEA type 2 family protein -
PAC42_RS00680 (PAC42_00680) 144459..144800 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PAC42_RS00685 (PAC42_00685) 144882..146309 - 1428 WP_003083784.1 GABA permease -
PAC42_RS00690 (PAC42_00690) 146478..147971 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T245582 WP_003083773.1 NZ_CP097560:c142765-142484 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT245582 WP_003083775.1 NZ_CP097560:c142989-142762 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References