Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4153448..4154067 Replicon chromosome
Accession NC_013850
Organism Klebsiella variicola At-22

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KVAR_RS19600 Protein ID WP_002892050.1
Coordinates 4153849..4154067 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1F2MBN7
Locus tag KVAR_RS19595 Protein ID WP_008805436.1
Coordinates 4153448..4153822 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVAR_RS19585 4148603..4149796 + 1194 WP_008805438.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KVAR_RS19590 4149819..4152965 + 3147 WP_012968813.1 multidrug efflux RND transporter permease subunit -
KVAR_RS19595 4153448..4153822 + 375 WP_008805436.1 Hha toxicity modulator TomB Antitoxin
KVAR_RS19600 4153849..4154067 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
KVAR_RS19605 4154226..4154792 + 567 WP_008805435.1 maltose O-acetyltransferase -
KVAR_RS28280 4154764..4154892 - 129 Protein_3978 hypothetical protein -
KVAR_RS19610 4154929..4155399 + 471 WP_008805434.1 YlaC family protein -
KVAR_RS19615 4155368..4156825 - 1458 WP_012968814.1 PLP-dependent aminotransferase family protein -
KVAR_RS19620 4156926..4157624 + 699 WP_012968815.1 GNAT family N-acetyltransferase -
KVAR_RS19625 4157621..4157761 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KVAR_RS19630 4157761..4158024 - 264 WP_008805431.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T24558 WP_002892050.1 NC_013850:4153849-4154067 [Klebsiella variicola At-22]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T24558 NC_013850:4153849-4154067 [Klebsiella variicola At-22]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14384.06 Da        Isoelectric Point: 4.8989

>AT24558 WP_008805436.1 NC_013850:4153448-4153822 [Klebsiella variicola At-22]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYTEDNKLVAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT24558 NC_013850:4153448-4153822 [Klebsiella variicola At-22]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MBN7

References