Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5064768..5066026 Replicon chromosome
Accession NZ_CP097557
Organism Pseudomonas aeruginosa strain C1.3

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PAC13_RS24375 Protein ID WP_003086331.1
Coordinates 5064768..5065523 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PAC13_RS24380 Protein ID WP_003086329.1
Coordinates 5065658..5066026 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC13_RS24365 (PAC13_24315) 5059939..5062482 + 2544 WP_009315399.1 acyl-homoserine-lactone acylase QuiP -
PAC13_RS24370 (PAC13_24320) 5062637..5063998 - 1362 WP_003134034.1 DNA recombination protein RmuC -
PAC13_RS24375 (PAC13_24325) 5064768..5065523 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PAC13_RS24380 (PAC13_24330) 5065658..5066026 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PAC13_RS24385 (PAC13_24335) 5066099..5067385 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PAC13_RS24390 (PAC13_24340) 5067441..5069030 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PAC13_RS24395 (PAC13_24345) 5069109..5069585 + 477 WP_003112531.1 hypothetical protein -
PAC13_RS24400 (PAC13_24350) 5069588..5069863 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T245579 WP_003086331.1 NZ_CP097557:c5065523-5064768 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT245579 WP_003086329.1 NZ_CP097557:c5066026-5065658 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References