Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4171457..4172678 Replicon chromosome
Accession NZ_CP097557
Organism Pseudomonas aeruginosa strain C1.3

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PAC13_RS20170 Protein ID WP_003110488.1
Coordinates 4172100..4172678 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PAC13_RS20165 Protein ID WP_003088112.1
Coordinates 4171457..4172011 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC13_RS20140 (PAC13_20095) 4167025..4167576 + 552 WP_003132721.1 XRE family transcriptional regulator -
PAC13_RS20145 (PAC13_20100) 4167573..4167971 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PAC13_RS20150 (PAC13_20105) 4167984..4168307 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PAC13_RS20155 (PAC13_20110) 4168638..4169099 + 462 WP_003088117.1 (2Fe-2S)-binding protein -
PAC13_RS20160 (PAC13_20115) 4169104..4171299 + 2196 WP_023091929.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PAC13_RS20165 (PAC13_20120) 4171457..4172011 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PAC13_RS20170 (PAC13_20125) 4172100..4172678 + 579 WP_003110488.1 HD domain-containing protein Toxin
PAC13_RS20175 (PAC13_20130) 4172788..4173975 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PAC13_RS20180 (PAC13_20135) 4173965..4176136 - 2172 WP_003110490.1 type I secretion system permease/ATPase -
PAC13_RS20185 (PAC13_20140) 4176126..4177403 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T245578 WP_003110488.1 NZ_CP097557:4172100-4172678 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT245578 WP_003088112.1 NZ_CP097557:4171457-4172011 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References