245576

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1120106..1120799 Replicon chromosome
Accession NZ_CP097557
Organism Pseudomonas aeruginosa strain C1.3

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag PAC13_RS05450 Protein ID WP_003151133.1
Coordinates 1120106..1120483 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag PAC13_RS05455 Protein ID WP_001172026.1
Coordinates 1120464..1120799 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC13_RS05440 (PAC13_05435) 1116299..1119328 - 3030 WP_010799689.1 Tn3 family transposase -
PAC13_RS05445 (PAC13_05440) 1119312..1119914 - 603 WP_010465829.1 recombinase family protein -
PAC13_RS05450 (PAC13_05445) 1120106..1120483 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAC13_RS05455 (PAC13_05450) 1120464..1120799 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
PAC13_RS05460 (PAC13_05455) 1120814..1121149 + 336 WP_000741275.1 hypothetical protein -
PAC13_RS05465 (PAC13_05460) 1121173..1121499 + 327 WP_000091614.1 hypothetical protein -
PAC13_RS05470 (PAC13_05465) 1121496..1121867 + 372 WP_023103794.1 hypothetical protein -
PAC13_RS05475 1121970..1122095 + 126 WP_256675080.1 hypothetical protein -
PAC13_RS05480 (PAC13_05470) 1122092..1122772 + 681 WP_049267373.1 hypothetical protein -
PAC13_RS05485 (PAC13_05475) 1122796..1123770 - 975 WP_042853537.1 SGNH/GDSL hydrolase family protein -
PAC13_RS05490 (PAC13_05480) 1123939..1124406 - 468 WP_042853536.1 hypothetical protein -
PAC13_RS05495 (PAC13_05485) 1124488..1125057 - 570 WP_023121486.1 LemA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aph(3')-IIb / blaPAO mucE 805694..1356337 550643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T245576 WP_003151133.1 NZ_CP097557:1120106-1120483 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT245576 WP_001172026.1 NZ_CP097557:1120464-1120799 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References