Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 149181..149686 Replicon chromosome
Accession NZ_CP097557
Organism Pseudomonas aeruginosa strain C1.3

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PAC13_RS00695 Protein ID WP_003083773.1
Coordinates 149181..149462 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PAC13_RS00700 Protein ID WP_003083775.1
Coordinates 149459..149686 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC13_RS00670 (PAC13_00670) 144432..145781 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PAC13_RS00675 (PAC13_00675) 145830..146516 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PAC13_RS00680 (PAC13_00680) 146617..147351 + 735 WP_003083764.1 GntR family transcriptional regulator -
PAC13_RS00685 (PAC13_00685) 147531..147941 + 411 WP_003110659.1 aegerolysin family protein -
PAC13_RS00690 (PAC13_00690) 147973..148881 - 909 WP_003083769.1 LysR family transcriptional regulator -
PAC13_RS00695 (PAC13_00695) 149181..149462 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PAC13_RS00700 (PAC13_00700) 149459..149686 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PAC13_RS00705 (PAC13_00705) 149862..150482 - 621 WP_023092259.1 hypothetical protein -
PAC13_RS00710 (PAC13_00710) 150583..151083 + 501 WP_003101228.1 LEA type 2 family protein -
PAC13_RS00715 (PAC13_00715) 151156..151497 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PAC13_RS00720 (PAC13_00720) 151579..153006 - 1428 WP_023092260.1 GABA permease -
PAC13_RS00725 (PAC13_00725) 153175..154668 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T245575 WP_003083773.1 NZ_CP097557:c149462-149181 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT245575 WP_003083775.1 NZ_CP097557:c149686-149459 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References