Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4470733..4471991 Replicon chromosome
Accession NZ_CP097556
Organism Pseudomonas aeruginosa strain B2.1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M8Z96_RS20730 Protein ID WP_003163133.1
Coordinates 4470733..4471488 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M8Z96_RS20735 Protein ID WP_003086329.1
Coordinates 4471623..4471991 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z96_RS20720 (M8Z96_20695) 4465905..4468448 + 2544 WP_031630217.1 acyl-homoserine-lactone acylase QuiP -
M8Z96_RS20725 (M8Z96_20700) 4468603..4469964 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M8Z96_RS20730 (M8Z96_20705) 4470733..4471488 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
M8Z96_RS20735 (M8Z96_20710) 4471623..4471991 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M8Z96_RS20740 (M8Z96_20715) 4472064..4473350 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
M8Z96_RS20745 (M8Z96_20720) 4473406..4474995 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
M8Z96_RS20750 (M8Z96_20725) 4475073..4475549 + 477 WP_031675481.1 elongation factor GreAB -
M8Z96_RS20755 (M8Z96_20730) 4475552..4475827 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T245573 WP_003163133.1 NZ_CP097556:c4471488-4470733 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT245573 WP_003086329.1 NZ_CP097556:c4471991-4471623 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References