245572

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3515056..3516277 Replicon chromosome
Accession NZ_CP097556
Organism Pseudomonas aeruginosa strain B2.1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M8Z96_RS16255 Protein ID WP_003102740.1
Coordinates 3515699..3516277 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M8Z96_RS16250 Protein ID WP_043089772.1
Coordinates 3515056..3515610 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z96_RS16225 (M8Z96_16205) 3510624..3511175 + 552 WP_003102727.1 XRE family transcriptional regulator -
M8Z96_RS16230 (M8Z96_16210) 3511172..3511570 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M8Z96_RS16235 (M8Z96_16215) 3511583..3511906 - 324 WP_023119961.1 multidrug efflux SMR transporter -
M8Z96_RS16240 (M8Z96_16220) 3512237..3512698 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M8Z96_RS16245 (M8Z96_16225) 3512703..3514898 + 2196 WP_043089773.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M8Z96_RS16250 (M8Z96_16230) 3515056..3515610 + 555 WP_043089772.1 helix-turn-helix transcriptional regulator Antitoxin
M8Z96_RS16255 (M8Z96_16235) 3515699..3516277 + 579 WP_003102740.1 HD domain-containing protein Toxin
M8Z96_RS16260 (M8Z96_16240) 3516386..3517573 - 1188 WP_021264658.1 HlyD family efflux transporter periplasmic adaptor subunit -
M8Z96_RS16265 (M8Z96_16245) 3517563..3519734 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
M8Z96_RS16270 (M8Z96_16250) 3519724..3521001 - 1278 WP_019396178.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T245572 WP_003102740.1 NZ_CP097556:3515699-3516277 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20484.66 Da        Isoelectric Point: 8.1590

>AT245572 WP_043089772.1 NZ_CP097556:3515056-3515610 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGTRLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References