245570

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143248..143753 Replicon chromosome
Accession NZ_CP097556
Organism Pseudomonas aeruginosa strain B2.1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M8Z96_RS00665 Protein ID WP_003083773.1
Coordinates 143248..143529 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M8Z96_RS00670 Protein ID WP_003083775.1
Coordinates 143526..143753 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z96_RS00640 (M8Z96_00640) 138499..139848 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
M8Z96_RS00645 (M8Z96_00645) 139897..140583 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M8Z96_RS00650 (M8Z96_00650) 140684..141418 + 735 WP_043089546.1 GntR family transcriptional regulator -
M8Z96_RS00655 (M8Z96_00655) 141598..142008 + 411 WP_003101225.1 aegerolysin family protein -
M8Z96_RS00660 (M8Z96_00660) 142040..142948 - 909 WP_003083769.1 LysR family transcriptional regulator -
M8Z96_RS00665 (M8Z96_00665) 143248..143529 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M8Z96_RS00670 (M8Z96_00670) 143526..143753 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M8Z96_RS00675 (M8Z96_00675) 143929..144549 - 621 WP_003101226.1 hypothetical protein -
M8Z96_RS00680 (M8Z96_00680) 144650..145150 + 501 WP_003101228.1 LEA type 2 family protein -
M8Z96_RS00685 (M8Z96_00685) 145223..145564 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M8Z96_RS00690 (M8Z96_00690) 145646..147073 - 1428 WP_003083784.1 GABA permease -
M8Z96_RS00695 (M8Z96_00695) 147242..148735 - 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T245570 WP_003083773.1 NZ_CP097556:c143529-143248 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT245570 WP_003083775.1 NZ_CP097556:c143753-143526 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References