Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1869887..1871395 Replicon chromosome
Accession NZ_CP097555
Organism Pseudomonas aeruginosa strain B1.2

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag M8Z32_RS08680 Protein ID WP_003119682.1
Coordinates 1869887..1870474 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag M8Z32_RS08685 Protein ID WP_033973484.1
Coordinates 1870541..1871395 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z32_RS08675 (M8Z32_08670) 1866142..1869621 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
M8Z32_RS08680 (M8Z32_08675) 1869887..1870474 + 588 WP_003119682.1 GNAT family protein Toxin
M8Z32_RS08685 (M8Z32_08680) 1870541..1871395 + 855 WP_033973484.1 AraC family transcriptional regulator Antitoxin
M8Z32_RS08690 (M8Z32_08685) 1871492..1873657 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
M8Z32_RS08695 (M8Z32_08690) 1873832..1875706 + 1875 WP_003117607.1 MFS transporter -
M8Z32_RS08700 (M8Z32_08695) 1875767..1875976 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T245566 WP_003119682.1 NZ_CP097555:1869887-1870474 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31921.23 Da        Isoelectric Point: 7.5295

>AT245566 WP_033973484.1 NZ_CP097555:1870541-1871395 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVPPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References