Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4844767..4845586 Replicon chromosome
Accession NZ_CP097554
Organism Klebsiella michiganensis strain YZUMF202001

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag M8333_RS22890 Protein ID WP_004110819.1
Coordinates 4845329..4845586 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag M8333_RS22885 Protein ID WP_128696737.1
Coordinates 4844767..4845318 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8333_RS22865 (M8333_22865) 4840987..4841895 - 909 WP_128696738.1 transcriptional regulator GcvA -
M8333_RS22870 (M8333_22870) 4842015..4842902 + 888 WP_064405204.1 DMT family transporter -
M8333_RS22875 (M8333_22875) 4843121..4843867 - 747 WP_224227290.1 class I SAM-dependent methyltransferase -
M8333_RS22880 (M8333_22880) 4844291..4844653 - 363 Protein_4502 class I SAM-dependent methyltransferase -
M8333_RS22885 (M8333_22885) 4844767..4845318 - 552 WP_128696737.1 N-acetyltransferase Antitoxin
M8333_RS22890 (M8333_22890) 4845329..4845586 - 258 WP_004110819.1 YjhX family toxin Toxin
M8333_RS22895 (M8333_22895) 4846262..4847446 + 1185 WP_014228054.1 mannonate dehydratase -
M8333_RS22900 (M8333_22900) 4847520..4848995 + 1476 WP_128696736.1 fructuronate reductase -
M8333_RS22905 (M8333_22905) 4849134..4849910 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T245562 WP_004110819.1 NZ_CP097554:c4845586-4845329 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20064.84 Da        Isoelectric Point: 6.3270

>AT245562 WP_128696737.1 NZ_CP097554:c4845318-4844767 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQTVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References