Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 663717..664309 Replicon chromosome
Accession NZ_CP097554
Organism Klebsiella michiganensis strain YZUMF202001

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag M8333_RS03215 Protein ID WP_004105955.1
Coordinates 663935..664309 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag M8333_RS03210 Protein ID WP_004105957.1
Coordinates 663717..663938 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8333_RS03190 (M8333_03195) 659274..659828 + 555 WP_014226934.1 YgjV family protein -
M8333_RS03195 (M8333_03200) 659847..661094 - 1248 WP_004105963.1 serine/threonine transporter SstT -
M8333_RS03200 (M8333_03205) 661349..662317 - 969 WP_048260487.1 TerC family protein -
M8333_RS03205 (M8333_03210) 662568..663557 - 990 WP_057173194.1 Gfo/Idh/MocA family oxidoreductase -
M8333_RS03210 (M8333_03215) 663717..663938 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M8333_RS03215 (M8333_03220) 663935..664309 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
M8333_RS03220 (M8333_03225) 664289..664792 - 504 WP_004105953.1 M48 family metallopeptidase -
M8333_RS03225 (M8333_03230) 664871..666514 - 1644 WP_224266337.1 glycoside hydrolase family 43 protein -
M8333_RS03230 (M8333_03235) 666643..667509 - 867 WP_224266338.1 AraC family transcriptional regulator -
M8333_RS03235 (M8333_03240) 667617..668960 + 1344 WP_025108308.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T245553 WP_004105955.1 NZ_CP097554:663935-664309 [Klebsiella michiganensis]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT245553 WP_004105957.1 NZ_CP097554:663717-663938 [Klebsiella michiganensis]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References