245552

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 65245..65792 Replicon chromosome
Accession NZ_CP097554
Organism Klebsiella michiganensis strain YZUMF202001

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag M8333_RS00320 Protein ID WP_122116989.1
Coordinates 65245..65553 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3H0P7
Locus tag M8333_RS00325 Protein ID WP_014227298.1
Coordinates 65556..65792 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8333_RS00295 (M8333_00295) 61161..61472 - 312 WP_014227304.1 PTS sugar transporter subunit IIB -
M8333_RS00300 (M8333_00300) 61767..62708 + 942 WP_014227303.1 LacI family DNA-binding transcriptional regulator -
M8333_RS00305 (M8333_00305) 62732..63025 - 294 WP_014227302.1 YicS family protein -
M8333_RS00310 (M8333_00310) 63235..64188 + 954 WP_116280588.1 Rpn family recombination-promoting nuclease/putative transposase -
M8333_RS00315 (M8333_00315) 64192..65094 - 903 WP_009654083.1 DMT family transporter -
M8333_RS00320 (M8333_00320) 65245..65553 - 309 WP_122116989.1 CcdB family protein Toxin
M8333_RS00325 (M8333_00325) 65556..65792 - 237 WP_014227298.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
M8333_RS00330 (M8333_00330) 65898..67331 - 1434 WP_032718833.1 PTS N-acetylmuramic acid transporter subunit IIBC -
M8333_RS00335 (M8333_00335) 67356..68258 - 903 WP_032752002.1 N-acetylmuramic acid 6-phosphate etherase -
M8333_RS00340 (M8333_00340) 68419..69585 - 1167 WP_014227296.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11706.52 Da        Isoelectric Point: 6.8684

>T245552 WP_122116989.1 NZ_CP097554:c65553-65245 [Klebsiella michiganensis]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHHVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8783.92 Da        Isoelectric Point: 5.7928

>AT245552 WP_014227298.1 NZ_CP097554:c65792-65556 [Klebsiella michiganensis]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H0P7

References