245551

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 91605..92217 Replicon plasmid pDFL36-03
Accession NZ_CP097550
Organism Dinoroseobacter shibae strain DFL-36

Toxin (Protein)


Gene name vapC Uniprot ID A0A840CKU8
Locus tag M8007_RS20665 Protein ID WP_012187367.1
Coordinates 91822..92217 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M8007_RS20660 Protein ID WP_012187366.1
Coordinates 91605..91832 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8007_RS20645 (M8007_20645) 87678..88913 - 1236 WP_012187363.1 plasmid replication protein RepC -
M8007_RS20650 (M8007_20650) 89091..90107 - 1017 WP_012187364.1 plasmid partitioning protein RepB -
M8007_RS20655 (M8007_20655) 90104..91291 - 1188 WP_012187365.1 plasmid partitioning protein RepA -
M8007_RS20660 (M8007_20660) 91605..91832 + 228 WP_012187366.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M8007_RS20665 (M8007_20665) 91822..92217 + 396 WP_012187367.1 PIN domain-containing protein Toxin
M8007_RS20670 (M8007_20670) 92201..93097 - 897 WP_012187368.1 recombinase family protein -
M8007_RS20675 (M8007_20675) 93156..94274 - 1119 WP_012187369.1 tyrosine-type recombinase/integrase -
M8007_RS20680 (M8007_20680) 94401..95285 + 885 WP_249994546.1 DUF1403 family protein -
M8007_RS20685 (M8007_20685) 95288..95905 + 618 WP_012187055.1 SMC-Scp complex subunit ScpB -
M8007_RS20690 (M8007_20690) 95955..96218 + 264 WP_012187054.1 WGR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..126307 126307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-42)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14296.32 Da        Isoelectric Point: 4.2692

>T245551 WP_012187367.1 NZ_CP097550:91822-92217 [Dinoroseobacter shibae]
MSAEFADTNVVLYLLDDGPKAERAEEILGQGPRISVQVLNEAMVNCRRKAGLSWEDTGAFLEGITSVCPVEGLTVQTHQV
GRALAEKYQLSVYDAMIVSAALIAGCTTLWTEDMHDGLLVEDRLRIVNPFA

Download         Length: 396 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8599.92 Da        Isoelectric Point: 11.1585

>AT245551 WP_012187366.1 NZ_CP097550:91605-91832 [Dinoroseobacter shibae]
MQVAKWGNSLAVRLPADLVRELGLKEGDQVDLVKDDGTILVRRQPRADEVLQGLRRFRRKLPKDARLSRDAAHER

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A840CKU8

Antitoxin

Source ID Structure

References