245550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 67147..67688 Replicon plasmid pDFL36-01
Accession NZ_CP097548
Organism Dinoroseobacter shibae strain DFL-36

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M8007_RS18830 Protein ID WP_044029371.1
Coordinates 67362..67688 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M8007_RS18825 Protein ID WP_012187139.1
Coordinates 67147..67365 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8007_RS18810 (M8007_18810) 63298..64170 + 873 WP_012187142.1 site-specific integrase -
M8007_RS18815 (M8007_18815) 64183..65385 + 1203 WP_012187141.1 IS91 family transposase -
M8007_RS18820 (M8007_18820) 65753..67048 - 1296 WP_050757916.1 DUF4010 domain-containing protein -
M8007_RS18825 (M8007_18825) 67147..67365 + 219 WP_012187139.1 antitoxin MazE family protein Antitoxin
M8007_RS18830 (M8007_18830) 67362..67688 + 327 WP_044029371.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M8007_RS18835 (M8007_18835) 67856..68140 - 285 WP_157865439.1 DUF4258 domain-containing protein -
M8007_RS18840 (M8007_18840) 68445..68645 - 201 WP_044029373.1 hypothetical protein -
M8007_RS18845 (M8007_18845) 68732..69094 - 363 WP_012187136.1 zf-TFIIB domain-containing protein -
M8007_RS18850 (M8007_18850) 69101..69835 - 735 WP_012187135.1 Bax inhibitor-1/YccA family protein -
M8007_RS18855 (M8007_18855) 70079..70765 - 687 WP_157865440.1 exopolysaccharide biosynthesis protein -
M8007_RS18860 (M8007_18860) 70773..71738 - 966 WP_012187133.1 calcium/sodium antiporter -
M8007_RS18865 (M8007_18865) 71864..72325 - 462 WP_012187132.1 pentapeptide repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..190506 190506


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(7-71)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11657.55 Da        Isoelectric Point: 7.2042

>T245550 WP_044029371.1 NZ_CP097548:67362-67688 [Dinoroseobacter shibae]
MRRGELVTVALQGDHGKPHPALVIQSDRFPDTATTTILMVTSTLVNAPLIRLTVEPASENGLRATSQIMIDKAMTVRTDK
LRGAFGQLDDTVMLEVNRALALFLGVTG

Download         Length: 327 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8074.26 Da        Isoelectric Point: 9.4896

>AT245550 WP_012187139.1 NZ_CP097548:67147-67365 [Dinoroseobacter shibae]
MPTPVSQRVKKRRDVLRAAGLRPVQIWVPDTRRPGFETECRRQAALVAQADRADVGLNGFIDAALIDMDGWD

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References