Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 938039..938841 Replicon chromosome
Accession NZ_CP097519
Organism Staphylococcus epidermidis strain C066

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag M8Z95_RS04490 Protein ID WP_002468490.1
Coordinates 938662..938841 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag M8Z95_RS04485 Protein ID WP_002486232.1
Coordinates 938039..938638 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z95_RS04460 (M8Z95_04460) 933251..934708 + 1458 WP_002440300.1 ABC transporter substrate-binding protein/permease -
M8Z95_RS04465 (M8Z95_04465) 934701..935423 + 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
M8Z95_RS04470 (M8Z95_04470) 935920..936069 + 150 WP_002468809.1 hypothetical protein -
M8Z95_RS04475 (M8Z95_04475) 936284..937414 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
M8Z95_RS04480 (M8Z95_04480) 937411..937881 + 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8Z95_RS04485 (M8Z95_04485) 938039..938638 + 600 WP_002486232.1 glucosamine-6-phosphate isomerase Antitoxin
M8Z95_RS04490 (M8Z95_04490) 938662..938841 + 180 WP_002468490.1 SAS053 family protein Toxin
M8Z95_RS04495 (M8Z95_04495) 938997..939401 + 405 WP_002485605.1 hypothetical protein -
M8Z95_RS04500 (M8Z95_04500) 939586..940971 + 1386 WP_001829862.1 class II fumarate hydratase -
M8Z95_RS04505 (M8Z95_04505) 941332..942156 - 825 WP_001829804.1 RluA family pseudouridine synthase -
M8Z95_RS04510 (M8Z95_04510) 942315..943448 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T245518 WP_002468490.1 NZ_CP097519:938662-938841 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22695.55 Da        Isoelectric Point: 4.8641

>AT245518 WP_002486232.1 NZ_CP097519:938039-938638 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGNLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure

References