Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 800478..801007 Replicon chromosome
Accession NZ_CP097519
Organism Staphylococcus epidermidis strain C066

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag M8Z95_RS03690 Protein ID WP_001829891.1
Coordinates 800645..801007 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag M8Z95_RS03685 Protein ID WP_001829931.1
Coordinates 800478..800648 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z95_RS03660 (M8Z95_03660) 796302..796781 + 480 WP_002457111.1 PH domain-containing protein -
M8Z95_RS03665 (M8Z95_03665) 796774..798279 + 1506 WP_002505951.1 PH domain-containing protein -
M8Z95_RS03670 (M8Z95_03670) 798266..798775 + 510 WP_002457109.1 PH domain-containing protein -
M8Z95_RS03675 (M8Z95_03675) 798823..799176 + 354 WP_002457108.1 holo-ACP synthase -
M8Z95_RS03680 (M8Z95_03680) 799243..800391 + 1149 WP_002457107.1 alanine racemase -
M8Z95_RS03685 (M8Z95_03685) 800478..800648 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
M8Z95_RS03690 (M8Z95_03690) 800645..801007 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M8Z95_RS03695 (M8Z95_03695) 801352..802353 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
M8Z95_RS03700 (M8Z95_03700) 802453..802779 + 327 WP_001829952.1 anti-sigma factor antagonist -
M8Z95_RS03705 (M8Z95_03705) 802781..803260 + 480 WP_001829903.1 anti-sigma B factor RsbW -
M8Z95_RS03710 (M8Z95_03710) 803235..804005 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T245517 WP_001829891.1 NZ_CP097519:800645-801007 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT245517 WP_001829931.1 NZ_CP097519:800478-800648 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References