245516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 789293..789802 Replicon chromosome
Accession NZ_CP097519
Organism Staphylococcus epidermidis strain C066

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag M8Z95_RS03630 Protein ID WP_001829980.1
Coordinates 789593..789802 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag M8Z95_RS03625 Protein ID WP_001829893.1
Coordinates 789293..789586 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z95_RS03600 (M8Z95_03600) 784302..785090 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
M8Z95_RS03605 (M8Z95_03605) 785096..785734 + 639 WP_002505076.1 thiamine phosphate synthase -
M8Z95_RS03610 (M8Z95_03610) 785823..786695 + 873 WP_002470121.1 membrane protein insertase YidC -
M8Z95_RS03615 (M8Z95_03615) 786801..787454 - 654 WP_001829983.1 HD domain-containing protein -
M8Z95_RS03620 (M8Z95_03620) 787636..789119 - 1484 Protein_713 cardiolipin synthase -
M8Z95_RS03625 (M8Z95_03625) 789293..789586 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
M8Z95_RS03630 (M8Z95_03630) 789593..789802 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
M8Z95_RS03635 (M8Z95_03635) 789945..790082 + 138 WP_001829949.1 Lmo0850 family protein -
M8Z95_RS03640 (M8Z95_03640) 790181..791392 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
M8Z95_RS03645 (M8Z95_03645) 791783..792856 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
M8Z95_RS03650 (M8Z95_03650) 792868..794223 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T245516 WP_001829980.1 NZ_CP097519:789593-789802 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT245516 WP_001829893.1 NZ_CP097519:789293-789586 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References