Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 868127..868656 Replicon chromosome
Accession NZ_CP097514
Organism Staphylococcus epidermidis strain C034

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag M8Z30_RS04015 Protein ID WP_001829891.1
Coordinates 868294..868656 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag M8Z30_RS04010 Protein ID WP_001829931.1
Coordinates 868127..868297 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z30_RS03985 (M8Z30_03985) 863952..864431 + 480 WP_001829909.1 PH domain-containing protein -
M8Z30_RS03990 (M8Z30_03990) 864424..865929 + 1506 WP_001829976.1 PH domain-containing protein -
M8Z30_RS03995 (M8Z30_03995) 865916..866425 + 510 WP_001829888.1 PH domain-containing protein -
M8Z30_RS04000 (M8Z30_04000) 866473..866826 + 354 WP_001829915.1 holo-ACP synthase -
M8Z30_RS04005 (M8Z30_04005) 866892..868040 + 1149 WP_002468951.1 alanine racemase -
M8Z30_RS04010 (M8Z30_04010) 868127..868297 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
M8Z30_RS04015 (M8Z30_04015) 868294..868656 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M8Z30_RS04020 (M8Z30_04020) 869002..870003 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
M8Z30_RS04025 (M8Z30_04025) 870103..870429 + 327 WP_001829952.1 anti-sigma factor antagonist -
M8Z30_RS04030 (M8Z30_04030) 870431..870910 + 480 WP_002484520.1 anti-sigma B factor RsbW -
M8Z30_RS04035 (M8Z30_04035) 870885..871655 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T245513 WP_001829891.1 NZ_CP097514:868294-868656 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT245513 WP_001829931.1 NZ_CP097514:868127-868297 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References