Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 868129..868658 Replicon chromosome
Accession NZ_CP097512
Organism Staphylococcus epidermidis strain C019

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag M8Z31_RS04015 Protein ID WP_001829891.1
Coordinates 868296..868658 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag M8Z31_RS04010 Protein ID WP_001829931.1
Coordinates 868129..868299 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z31_RS03985 (M8Z31_03985) 863954..864433 + 480 WP_001829909.1 PH domain-containing protein -
M8Z31_RS03990 (M8Z31_03990) 864426..865931 + 1506 WP_001829976.1 PH domain-containing protein -
M8Z31_RS03995 (M8Z31_03995) 865918..866427 + 510 WP_001829888.1 PH domain-containing protein -
M8Z31_RS04000 (M8Z31_04000) 866475..866828 + 354 WP_001829915.1 holo-ACP synthase -
M8Z31_RS04005 (M8Z31_04005) 866894..868042 + 1149 WP_002468951.1 alanine racemase -
M8Z31_RS04010 (M8Z31_04010) 868129..868299 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
M8Z31_RS04015 (M8Z31_04015) 868296..868658 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M8Z31_RS04020 (M8Z31_04020) 869004..870005 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
M8Z31_RS04025 (M8Z31_04025) 870105..870431 + 327 WP_001829952.1 anti-sigma factor antagonist -
M8Z31_RS04030 (M8Z31_04030) 870433..870912 + 480 WP_002484520.1 anti-sigma B factor RsbW -
M8Z31_RS04035 (M8Z31_04035) 870887..871657 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T245509 WP_001829891.1 NZ_CP097512:868296-868658 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT245509 WP_001829931.1 NZ_CP097512:868129-868299 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References