Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 856946..857455 Replicon chromosome
Accession NZ_CP097512
Organism Staphylococcus epidermidis strain C019

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag M8Z31_RS03955 Protein ID WP_001829980.1
Coordinates 857246..857455 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag M8Z31_RS03950 Protein ID WP_001829893.1
Coordinates 856946..857239 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z31_RS03925 (M8Z31_03925) 851954..852742 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
M8Z31_RS03930 (M8Z31_03930) 852748..853386 + 639 WP_002505076.1 thiamine phosphate synthase -
M8Z31_RS03935 (M8Z31_03935) 853475..854347 + 873 WP_002458703.1 membrane protein insertase YidC -
M8Z31_RS03940 (M8Z31_03940) 854453..855106 - 654 WP_001829983.1 HD domain-containing protein -
M8Z31_RS03945 (M8Z31_03945) 855288..856772 - 1485 WP_250067763.1 cardiolipin synthase -
M8Z31_RS03950 (M8Z31_03950) 856946..857239 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
M8Z31_RS03955 (M8Z31_03955) 857246..857455 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
M8Z31_RS03960 (M8Z31_03960) 857598..857735 + 138 WP_001829949.1 Lmo0850 family protein -
M8Z31_RS03965 (M8Z31_03965) 857835..859046 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
M8Z31_RS03970 (M8Z31_03970) 859437..860510 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
M8Z31_RS03975 (M8Z31_03975) 860522..861877 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T245508 WP_001829980.1 NZ_CP097512:857246-857455 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT245508 WP_001829893.1 NZ_CP097512:856946-857239 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References