245497

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1321017..1321934 Replicon chromosome
Accession NZ_CP097467
Organism Bacillus velezensis strain HMB26553

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag M8X21_RS07050 Protein ID WP_007407256.1
Coordinates 1321188..1321934 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M8X21_RS07045 Protein ID WP_003154807.1
Coordinates 1321017..1321187 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8X21_RS07005 (M8X21_07005) 1316229..1317818 + 1590 WP_029973066.1 hypothetical protein -
M8X21_RS07010 (M8X21_07010) 1317831..1318256 + 426 WP_029973065.1 hypothetical protein -
M8X21_RS07015 (M8X21_07015) 1318261..1318458 + 198 WP_007610833.1 XkdX family protein -
M8X21_RS07020 (M8X21_07020) 1318515..1319276 + 762 WP_029973064.1 hypothetical protein -
M8X21_RS07025 (M8X21_07025) 1319328..1319591 + 264 WP_003154815.1 hemolysin XhlA family protein -
M8X21_RS07030 (M8X21_07030) 1319605..1319868 + 264 WP_003154813.1 phage holin -
M8X21_RS07035 (M8X21_07035) 1319882..1320760 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
M8X21_RS07040 (M8X21_07040) 1320795..1320920 - 126 WP_003154809.1 hypothetical protein -
M8X21_RS07045 (M8X21_07045) 1321017..1321187 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M8X21_RS07050 (M8X21_07050) 1321188..1321934 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M8X21_RS07055 (M8X21_07055) 1322038..1323036 - 999 WP_003154805.1 inorganic phosphate transporter -
M8X21_RS07060 (M8X21_07060) 1323049..1323666 - 618 WP_003154804.1 DUF47 domain-containing protein -
M8X21_RS07065 (M8X21_07065) 1323952..1325268 - 1317 WP_007610842.1 amino acid permease -
M8X21_RS07070 (M8X21_07070) 1325590..1326540 + 951 WP_007610844.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T245497 WP_007407256.1 NZ_CP097467:c1321934-1321188 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT245497 WP_003154807.1 NZ_CP097467:c1321187-1321017 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References