245495

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2477879..2478507 Replicon chromosome
Accession NZ_CP097464
Organism Leptospira borgpetersenii strain 34-PK

Toxin (Protein)


Gene name vapC Uniprot ID M6E4U3
Locus tag LIX26_RS10535 Protein ID WP_002724218.1
Coordinates 2478106..2478507 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LIX26_RS10530 Protein ID WP_010705987.1
Coordinates 2477879..2478109 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX26_RS10515 (LIX26_10515) 2475852..2476550 - 699 WP_002724172.1 hypothetical protein -
LIX26_RS10520 (LIX26_10520) 2476733..2476961 - 229 Protein_2080 hypothetical protein -
LIX26_RS10525 (LIX26_10525) 2477476..2477613 - 138 WP_002736206.1 hypothetical protein -
LIX26_RS10530 (LIX26_10530) 2477879..2478109 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LIX26_RS10535 (LIX26_10535) 2478106..2478507 + 402 WP_002724218.1 type II toxin-antitoxin system VapC family toxin Toxin
LIX26_RS10540 (LIX26_10540) 2478653..2478832 - 180 WP_002724268.1 hypothetical protein -
LIX26_RS10545 (LIX26_10545) 2478942..2480624 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
LIX26_RS10550 (LIX26_10550) 2481033..2481578 + 546 WP_170874669.1 metal-dependent hydrolase -
LIX26_RS10555 (LIX26_10555) 2482371..2482661 + 291 WP_002736220.1 YciI family protein -
LIX26_RS10560 (LIX26_10560) 2482670..2483366 - 697 Protein_2088 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15501.23 Da        Isoelectric Point: 9.9288

>T245495 WP_002724218.1 NZ_CP097464:2478106-2478507 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHFERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT245495 WP_010705987.1 NZ_CP097464:2477879-2478109 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M6E4U3

Antitoxin

Source ID Structure

References