245493

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 480477..481042 Replicon chromosome
Accession NZ_CP097464
Organism Leptospira borgpetersenii strain 34-PK

Toxin (Protein)


Gene name mazF Uniprot ID V6I350
Locus tag LIX26_RS02095 Protein ID WP_002753850.1
Coordinates 480477..480725 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LIX26_RS02100 Protein ID WP_011670965.1
Coordinates 480719..481042 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX26_RS02075 (LIX26_02075) 475526..476527 + 1002 WP_002732926.1 metallophosphoesterase -
LIX26_RS02080 (LIX26_02080) 476530..477207 + 678 WP_002725755.1 hypothetical protein -
LIX26_RS02085 (LIX26_02085) 477204..477620 + 417 WP_002725741.1 hypothetical protein -
LIX26_RS02090 (LIX26_02090) 477601..479781 + 2181 WP_002759426.1 ATP-dependent DNA helicase RecG -
LIX26_RS02095 (LIX26_02095) 480477..480725 + 249 WP_002753850.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
LIX26_RS02100 (LIX26_02100) 480719..481042 + 324 WP_011670965.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
LIX26_RS02105 (LIX26_02105) 481478..483013 + 1536 WP_002738394.1 phosphomethylpyrimidine synthase ThiC -
LIX26_RS02110 (LIX26_02110) 483392..484045 + 654 Protein_412 helicase-related protein -
LIX26_RS02115 (LIX26_02115) 484420..484764 - 345 WP_002728323.1 TIGR04452 family lipoprotein -
LIX26_RS02120 (LIX26_02120) 485098..485841 + 744 WP_002728313.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(6-49)

Antitoxin

mRNA interferase PemK-like

(5-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9459.00 Da        Isoelectric Point: 5.1749

>T245493 WP_002753850.1 NZ_CP097464:480477-480725 [Leptospira borgpetersenii]
MKALVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPREGWEKQFKSMSSNKDDKLLIPDSIDLSDKDW
EW

Download         Length: 249 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12296.80 Da        Isoelectric Point: 10.5161

>AT245493 WP_011670965.1 NZ_CP097464:480719-481042 [Leptospira borgpetersenii]
MVISQYEVYLINLDPTVGHEIKKSRPCVIISPNEMNKTIGTIIITPMTTKSRSYPTRVELTFQGKKGWIVLDQIRTVDKI
RLIKKLGKIDPKTVNKMKLIIKEMLVD

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6I350

Antitoxin

Source ID Structure

References