Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2391659..2392297 Replicon chromosome
Accession NZ_CP097430
Organism Escherichia coli strain C288

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag M8Y68_RS11640 Protein ID WP_001447010.1
Coordinates 2392121..2392297 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M8Y68_RS11635 Protein ID WP_001270286.1
Coordinates 2391659..2392075 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y68_RS11615 (2386811) 2386811..2387752 - 942 WP_001251304.1 ABC transporter permease -
M8Y68_RS11620 (2387753) 2387753..2388766 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M8Y68_RS11625 (2388784) 2388784..2389929 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M8Y68_RS11630 (2390174) 2390174..2391580 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M8Y68_RS11635 (2391659) 2391659..2392075 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M8Y68_RS11640 (2392121) 2392121..2392297 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M8Y68_RS11645 (2392519) 2392519..2392749 + 231 WP_000494244.1 YncJ family protein -
M8Y68_RS11650 (2392841) 2392841..2394802 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M8Y68_RS11655 (2394875) 2394875..2395411 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M8Y68_RS11660 (2395503) 2395503..2396678 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T245479 WP_001447010.1 NZ_CP097430:c2392297-2392121 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT245479 WP_001270286.1 NZ_CP097430:c2392075-2391659 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References