Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1767967..1768799 Replicon chromosome
Accession NZ_CP097430
Organism Escherichia coli strain C288

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag M8Y68_RS08425 Protein ID WP_095516956.1
Coordinates 1767967..1768341 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A646JF77
Locus tag M8Y68_RS08430 Protein ID WP_033873479.1
Coordinates 1768431..1768799 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y68_RS08390 (1764091) 1764091..1764286 - 196 Protein_1644 transposase -
M8Y68_RS08395 (1764489) 1764489..1764713 - 225 Protein_1645 IS110 family transposase -
M8Y68_RS08400 (1764820) 1764820..1765245 + 426 WP_000422741.1 transposase -
M8Y68_RS08405 (1765242) 1765242..1765592 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
M8Y68_RS08410 (1765623) 1765623..1767236 + 1614 WP_000080193.1 IS66-like element ISEc23 family transposase -
M8Y68_RS08415 (1767638) 1767638..1767718 - 81 Protein_1649 hypothetical protein -
M8Y68_RS08420 (1767818) 1767818..1767970 - 153 Protein_1650 DUF5983 family protein -
M8Y68_RS08425 (1767967) 1767967..1768341 - 375 WP_095516956.1 TA system toxin CbtA family protein Toxin
M8Y68_RS08430 (1768431) 1768431..1768799 - 369 WP_033873479.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M8Y68_RS08435 (1768962) 1768962..1769183 - 222 WP_000692345.1 DUF987 domain-containing protein -
M8Y68_RS08440 (1769246) 1769246..1769722 - 477 WP_001186774.1 RadC family protein -
M8Y68_RS08445 (1769738) 1769738..1770211 - 474 WP_053290119.1 antirestriction protein -
M8Y68_RS08450 (1770553) 1770553..1771371 - 819 WP_001765427.1 DUF932 domain-containing protein -
M8Y68_RS08455 (1771489) 1771489..1771684 - 196 Protein_1657 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14056.08 Da        Isoelectric Point: 7.2127

>T245472 WP_095516956.1 NZ_CP097430:c1768341-1767967 [Escherichia coli]
MKTLPDTHVREVSCCQSPVTIWQTLLTRLLDQYYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVSSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13620.45 Da        Isoelectric Point: 6.6255

>AT245472 WP_033873479.1 NZ_CP097430:c1768799-1768431 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYVKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A646JF77

References