Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 820229..820883 Replicon chromosome
Accession NZ_CP097430
Organism Escherichia coli strain C288

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag M8Y68_RS04025 Protein ID WP_000244777.1
Coordinates 820476..820883 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M8Y68_RS04020 Protein ID WP_000354046.1
Coordinates 820229..820495 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y68_RS03995 (815398) 815398..816141 + 744 WP_000951962.1 SDR family oxidoreductase -
M8Y68_RS04000 (816198) 816198..817631 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
M8Y68_RS04005 (817676) 817676..817987 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
M8Y68_RS04010 (818151) 818151..818810 + 660 WP_000250274.1 hemolysin III family protein -
M8Y68_RS04015 (819006) 819006..819986 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M8Y68_RS04020 (820229) 820229..820495 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M8Y68_RS04025 (820476) 820476..820883 + 408 WP_000244777.1 protein YgfX Toxin
M8Y68_RS04030 (820923) 820923..821444 - 522 WP_001055874.1 flavodoxin FldB -
M8Y68_RS04035 (821556) 821556..822452 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M8Y68_RS04040 (822477) 822477..823187 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M8Y68_RS04045 (823193) 823193..824926 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T245469 WP_000244777.1 NZ_CP097430:820476-820883 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT245469 WP_000354046.1 NZ_CP097430:820229-820495 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References