Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 774918..775575 Replicon chromosome
Accession NC_013850
Organism Klebsiella variicola At-22

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KVAR_RS03700 Protein ID WP_002916310.1
Coordinates 775165..775575 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KVAR_RS03695 Protein ID WP_002916312.1
Coordinates 774918..775184 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KVAR_RS03675 771412..772140 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
KVAR_RS03680 772191..772502 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
KVAR_RS03685 772666..773325 + 660 WP_008806429.1 hemolysin III family protein -
KVAR_RS03690 773689..774672 - 984 WP_012967246.1 tRNA-modifying protein YgfZ -
KVAR_RS03695 774918..775184 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KVAR_RS03700 775165..775575 + 411 WP_002916310.1 protein YgfX Toxin
KVAR_RS03705 775582..776103 - 522 WP_008806427.1 flavodoxin FldB -
KVAR_RS03710 776204..777100 + 897 WP_012967247.1 site-specific tyrosine recombinase XerD -
KVAR_RS03715 777123..777836 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KVAR_RS03720 777842..779575 + 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T24546 WP_002916310.1 NC_013850:775165-775575 [Klebsiella variicola At-22]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T24546 NC_013850:775165-775575 [Klebsiella variicola At-22]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGTTGGTTCCCTGGCCGCTAAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTAGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAATAGCGGTATGCTGCTGCGTTTACGCCATGTCGATACCCGGCGCGG
GCAGCATCTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT24546 WP_002916312.1 NC_013850:774918-775184 [Klebsiella variicola At-22]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT24546 NC_013850:774918-775184 [Klebsiella variicola At-22]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References