Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4012700..4013276 Replicon chromosome
Accession NZ_CP097426
Organism Escherichia coli strain C289

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag M8Y67_RS19590 Protein ID WP_001297643.1
Coordinates 4012989..4013276 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag M8Y67_RS19585 Protein ID WP_000063156.1
Coordinates 4012700..4013002 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y67_RS19570 (4009296) 4009296..4011446 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
M8Y67_RS19575 (4011496) 4011496..4011699 + 204 WP_000467859.1 YbdD/YjiX family protein -
M8Y67_RS19580 (4011710) 4011710..4012666 + 957 WP_001297640.1 GTPase -
M8Y67_RS19585 (4012700) 4012700..4013002 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
M8Y67_RS19590 (4012989) 4012989..4013276 - 288 WP_001297643.1 BrnT family toxin Toxin
M8Y67_RS19595 (4013475) 4013475..4014172 - 698 Protein_3849 IS1 family transposase -
M8Y67_RS19600 (4014229) 4014229..4014324 + 96 Protein_3850 dienelactone hydrolase family protein -
M8Y67_RS19605 (4014470) 4014470..4015702 + 1233 WP_001380906.1 multidrug efflux MFS transporter MdtM -
M8Y67_RS19610 (4015743) 4015743..4017023 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T245457 WP_001297643.1 NZ_CP097426:c4013276-4012989 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT245457 WP_000063156.1 NZ_CP097426:c4013002-4012700 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References