Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3455162..3455780 Replicon chromosome
Accession NZ_CP097426
Organism Escherichia coli strain C289

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M8Y67_RS16875 Protein ID WP_001291435.1
Coordinates 3455562..3455780 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M8Y67_RS16870 Protein ID WP_000344800.1
Coordinates 3455162..3455536 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y67_RS16860 (3450251) 3450251..3451444 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M8Y67_RS16865 (3451467) 3451467..3454616 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M8Y67_RS16870 (3455162) 3455162..3455536 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M8Y67_RS16875 (3455562) 3455562..3455780 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M8Y67_RS16880 (3455952) 3455952..3456503 + 552 WP_000102564.1 maltose O-acetyltransferase -
M8Y67_RS16885 (3456619) 3456619..3457089 + 471 WP_000136192.1 YlaC family protein -
M8Y67_RS16890 (3457253) 3457253..3458803 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M8Y67_RS16895 (3458845) 3458845..3459198 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M8Y67_RS16905 (3459577) 3459577..3459888 + 312 WP_000409911.1 MGMT family protein -
M8Y67_RS16910 (3459919) 3459919..3460491 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T245454 WP_001291435.1 NZ_CP097426:3455562-3455780 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT245454 WP_000344800.1 NZ_CP097426:3455162-3455536 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References