Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5390434..5390950 Replicon chromosome
Accession NZ_CP097423
Organism Klebsiella pneumoniae strain K153

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M8Y71_RS26570 Protein ID WP_002886902.1
Coordinates 5390434..5390718 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M8Y71_RS26575 Protein ID WP_002886901.1
Coordinates 5390708..5390950 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y71_RS26545 (M8Y71_26545) 5385918..5386181 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M8Y71_RS26550 (M8Y71_26550) 5386311..5386484 + 174 WP_002886906.1 hypothetical protein -
M8Y71_RS26555 (M8Y71_26555) 5386487..5387230 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M8Y71_RS26560 (M8Y71_26560) 5387587..5389725 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
M8Y71_RS26565 (M8Y71_26565) 5389966..5390430 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M8Y71_RS26570 (M8Y71_26570) 5390434..5390718 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8Y71_RS26575 (M8Y71_26575) 5390708..5390950 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M8Y71_RS26580 (M8Y71_26580) 5391028..5392938 - 1911 WP_004152270.1 PRD domain-containing protein -
M8Y71_RS26585 (M8Y71_26585) 5392961..5394115 - 1155 WP_002886900.1 lactonase family protein -
M8Y71_RS26590 (M8Y71_26590) 5394181..5394921 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T245438 WP_002886902.1 NZ_CP097423:c5390718-5390434 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245438 WP_002886901.1 NZ_CP097423:c5390950-5390708 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References