Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 5288341..5289151 Replicon chromosome
Accession NZ_CP097423
Organism Klebsiella pneumoniae strain K153

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag M8Y71_RS26090 Protein ID WP_002887280.1
Coordinates 5288341..5288874 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M8Y71_RS26095 Protein ID WP_002887278.1
Coordinates 5288885..5289151 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y71_RS26085 (M8Y71_26085) 5287172..5288293 + 1122 WP_002887282.1 cupin domain-containing protein -
M8Y71_RS26090 (M8Y71_26090) 5288341..5288874 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
M8Y71_RS26095 (M8Y71_26095) 5288885..5289151 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M8Y71_RS26100 (M8Y71_26100) 5289254..5290687 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
M8Y71_RS26105 (M8Y71_26105) 5290677..5291360 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
M8Y71_RS26110 (M8Y71_26110) 5291532..5292917 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
M8Y71_RS26115 (M8Y71_26115) 5292935..5293279 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T245437 WP_002887280.1 NZ_CP097423:c5288874-5288341 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT245437 WP_002887278.1 NZ_CP097423:c5289151-5288885 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References