Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1..644 Replicon plasmid unnamed2
Accession NZ_CP097421
Organism Klebsiella pneumoniae strain K229

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag M8Y66_RS27130 Protein ID WP_000754566.1
Coordinates 228..644 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag M8Y66_RS27125 Protein ID WP_001261276.1
Coordinates 1..231 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y66_RS27125 (M8Y66_27125) 1..231 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M8Y66_RS27130 (M8Y66_27130) 228..644 + 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
M8Y66_RS27135 (M8Y66_27135) 848..1704 + 857 Protein_2 IS3-like element ISEc15 family transposase -
M8Y66_RS27140 (M8Y66_27140) 1986..2186 + 201 Protein_3 transposase -
M8Y66_RS27145 (M8Y66_27145) 2209..2631 + 423 WP_032446862.1 hypothetical protein -
M8Y66_RS27150 (M8Y66_27150) 2640..3137 + 498 WP_032446861.1 hypothetical protein -
M8Y66_RS27155 (M8Y66_27155) 3274..3609 - 336 Protein_6 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aac(6')-Ib-cr / blaOXA-1 / dfrA12 / aadA2 / qacE / sul1 / mph(A) - 1..96910 96910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15006.52 Da        Isoelectric Point: 9.2957

>T245423 WP_000754566.1 NZ_CP097421:228-644 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT245423 WP_001261276.1 NZ_CP097421:1-231 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References