Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2393486..2394002 Replicon chromosome
Accession NZ_CP097419
Organism Klebsiella pneumoniae strain K229

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag M8Y66_RS11555 Protein ID WP_002886902.1
Coordinates 2393718..2394002 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M8Y66_RS11550 Protein ID WP_002886901.1
Coordinates 2393486..2393728 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y66_RS11535 (M8Y66_11535) 2389515..2390255 + 741 WP_002886899.1 KDGP aldolase family protein -
M8Y66_RS11540 (M8Y66_11540) 2390321..2391475 + 1155 WP_002886900.1 lactonase family protein -
M8Y66_RS11545 (M8Y66_11545) 2391498..2393408 + 1911 WP_004152270.1 PRD domain-containing protein -
M8Y66_RS11550 (M8Y66_11550) 2393486..2393728 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M8Y66_RS11555 (M8Y66_11555) 2393718..2394002 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8Y66_RS11560 (M8Y66_11560) 2394006..2394470 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M8Y66_RS11565 (M8Y66_11565) 2394711..2396849 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
M8Y66_RS11570 (M8Y66_11570) 2397206..2397949 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M8Y66_RS11575 (M8Y66_11575) 2397952..2398125 - 174 WP_002886906.1 hypothetical protein -
M8Y66_RS11580 (M8Y66_11580) 2398255..2398518 + 264 WP_004152271.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T245414 WP_002886902.1 NZ_CP097419:2393718-2394002 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT245414 WP_002886901.1 NZ_CP097419:2393486-2393728 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References