Detailed information of TA system TA024541

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1644866..1645385
• Replicon: chromosome
• Accession: NC_013798
• Organism: Streptococcus gallolyticus UCN34

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F5WVW3
• Locus tag: GALLO_RS08115
• Protein ID: WP_012962242.1
• Coordinates: 1644866..1645144 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F5WVW4
• Locus tag: GALLO_RS08120
• Protein ID: WP_012962243.1
• Coordinates: 1645137..1645385 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GALLO_RS08085	1640185..1640793	-	609	WP_009854651.1	TVP38/TMEM64 family protein	-
GALLO_RS08095	1641041..1641341	-	301	Protein_1539	hypothetical protein	-
GALLO_RS08100	1641584..1643116	-	1533	WP_013643300.1	HAMP domain-containing histidine kinase	-
GALLO_RS08105	1643061..1643753	-	693	WP_012962240.1	response regulator transcription factor	-
GALLO_RS08110	1643859..1644737	-	879	WP_012962241.1	DUF3114 domain-containing protein	-
GALLO_RS08115	1644866..1645144	-	279	WP_012962242.1	type II toxin-antitoxin system YafQ family toxin	Toxin
GALLO_RS08120	1645137..1645385	-	249	WP_012962243.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GALLO_RS08125	1645712..1646230	+	519	WP_009854658.1	TetR/AcrR family transcriptional regulator	-
GALLO_RS08130	1646344..1648113	+	1770	WP_009854659.1	oleate hydratase	-
GALLO_RS08135	1648246..1649070	-	825	WP_043910976.1	class C sortase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11043.84 Da
• Isoelectric Point: 9.3104

>T24541 WP_012962242.1 NC_013798:c1645144-1644866 [Streptococcus gallolyticus UCN34]
MLKIKYHRQFKRDYKLALKRGLKASKLEEVLEILIKGESLPEKYRDHQLVASKYYQNVRECHIQPDWLLIYQIDDDNLIL
NLVRTGSHSDLF

Nucleotide

• Length: 279 bp

>T24541 NC_013798:c1645144-1644866 [Streptococcus gallolyticus UCN34]
ATGCTTAAAATTAAATACCACAGACAGTTTAAAAGGGATTATAAACTAGCTTTAAAACGTGGTTTAAAAGCTTCCAAACT
AGAGGAAGTCTTAGAAATTTTAATAAAGGGTGAAAGTTTACCAGAAAAATATAGAGACCACCAACTAGTGGCAAGTAAAT
ATTATCAAAATGTTAGAGAATGTCATATTCAGCCTGATTGGTTATTAATTTATCAGATTGATGATGATAATTTGATTTTG
AATTTAGTGCGAACGGGTAGTCATTCGGATTTATTTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9204.69 Da
• Isoelectric Point: 4.3193

>AT24541 WP_012962243.1 NC_013798:c1645385-1645137 [Streptococcus gallolyticus UCN34]
MTTITFKVDDEMKKEATELYKSMGLDLSSALRLFIKQSLVTRSIPFVIKADELTPVLDDVVKGVNMSEEFTDVKSLMESL
DA

Nucleotide

• Length: 249 bp

>AT24541 NC_013798:c1645385-1645137 [Streptococcus gallolyticus UCN34]
ATGACTACAATTACATTTAAAGTTGATGATGAAATGAAAAAGGAAGCAACTGAACTTTATAAATCAATGGGGCTAGATTT
ATCTAGTGCATTACGCTTGTTTATAAAGCAATCTCTTGTTACTCGTAGTATTCCTTTTGTTATTAAAGCTGATGAATTAA
CTCCTGTTCTTGATGATGTCGTAAAGGGTGTTAACATGAGTGAAGAATTTACTGATGTTAAAAGTTTGATGGAGAGTTTA
GATGCTTAA

Structures

Toxin

• AlphaFold DB: F5WVW3

Antitoxin

• AlphaFold DB: F5WVW4