Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 960876..961533 Replicon chromosome
Accession NZ_CP097419
Organism Klebsiella pneumoniae strain K229

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M8Y66_RS04475 Protein ID WP_002916310.1
Coordinates 960876..961286 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M8Y66_RS04480 Protein ID WP_002916312.1
Coordinates 961267..961533 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y66_RS04455 (M8Y66_04455) 956876..958609 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
M8Y66_RS04460 (M8Y66_04460) 958615..959328 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M8Y66_RS04465 (M8Y66_04465) 959351..960247 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M8Y66_RS04470 (M8Y66_04470) 960348..960869 + 522 WP_002916308.1 flavodoxin FldB -
M8Y66_RS04475 (M8Y66_04475) 960876..961286 - 411 WP_002916310.1 protein YgfX Toxin
M8Y66_RS04480 (M8Y66_04480) 961267..961533 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M8Y66_RS04485 (M8Y66_04485) 961779..962762 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M8Y66_RS04490 (M8Y66_04490) 962913..963572 - 660 WP_002916317.1 hemolysin III family protein -
M8Y66_RS04495 (M8Y66_04495) 963736..964047 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
M8Y66_RS04500 (M8Y66_04500) 964097..964825 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M8Y66_RS04505 (M8Y66_04505) 964944..966377 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T245408 WP_002916310.1 NZ_CP097419:c961286-960876 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT245408 WP_002916312.1 NZ_CP097419:c961533-961267 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References