Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4712369..4713072 Replicon chromosome
Accession NZ_CP097415
Organism Klebsiella pneumoniae strain K163

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M8Y70_RS23020 Protein ID WP_071994632.1
Coordinates 4712369..4712710 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M8Y70_RS23025 Protein ID WP_032434296.1
Coordinates 4712731..4713072 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y70_RS23010 (4708684) 4708684..4709553 + 870 WP_023317468.1 HNH endonuclease -
M8Y70_RS23015 (4710144) 4710144..4712177 + 2034 WP_050598589.1 hypothetical protein -
M8Y70_RS23020 (4712369) 4712369..4712710 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M8Y70_RS23025 (4712731) 4712731..4713072 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M8Y70_RS23030 (4713083) 4713083..4713625 - 543 WP_032434298.1 DNA repair protein RadC -
M8Y70_RS23035 (4713638) 4713638..4714078 - 441 WP_032434300.1 antirestriction protein -
M8Y70_RS23040 (4714109) 4714109..4714930 - 822 WP_032434301.1 DUF932 domain-containing protein -
M8Y70_RS23045 (4715050) 4715050..4715523 - 474 WP_032434303.1 hypothetical protein -
M8Y70_RS23050 (4715595) 4715595..4716047 - 453 WP_032410767.1 hypothetical protein -
M8Y70_RS23055 (4716083) 4716083..4716799 - 717 WP_032434305.1 WYL domain-containing protein -
M8Y70_RS23060 (4717043) 4717043..4717917 - 875 Protein_4525 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4700666..4746339 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T245403 WP_071994632.1 NZ_CP097415:c4712710-4712369 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT245403 WP_032434296.1 NZ_CP097415:c4713072-4712731 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References