Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2644591..2646179 Replicon chromosome
Accession NZ_CP097415
Organism Klebsiella pneumoniae strain K163

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag M8Y70_RS12935 Protein ID WP_004892016.1
Coordinates 2644591..2645913 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M8Y70_RS12940 Protein ID WP_004176198.1
Coordinates 2645913..2646179 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y70_RS12920 (2639647) 2639647..2642148 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
M8Y70_RS12925 (2642136) 2642136..2643140 + 1005 WP_032435338.1 fimbrial protein -
M8Y70_RS12930 (2643282) 2643282..2644574 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M8Y70_RS12935 (2644591) 2644591..2645913 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
M8Y70_RS12940 (2645913) 2645913..2646179 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M8Y70_RS12945 (2646566) 2646566..2646892 - 327 WP_004184023.1 hydroxyisourate hydrolase -
M8Y70_RS12950 (2646889) 2646889..2647389 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M8Y70_RS12955 (2647367) 2647367..2648746 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
M8Y70_RS12960 (2649092) 2649092..2650246 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M8Y70_RS12965 (2650227) 2650227..2651150 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T245400 WP_004892016.1 NZ_CP097415:c2645913-2644591 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT245400 WP_004176198.1 NZ_CP097415:c2646179-2645913 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References