Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1516449..1517029 Replicon chromosome
Accession NC_013798
Organism Streptococcus gallolyticus UCN34

Toxin (Protein)


Gene name hicA Uniprot ID F5WVJ0
Locus tag GALLO_RS07495 Protein ID WP_009854536.1
Coordinates 1516841..1517029 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F5WVI9
Locus tag GALLO_RS07490 Protein ID WP_012962171.1
Coordinates 1516449..1516829 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GALLO_RS07485 1514931..1515347 - 417 WP_012962170.1 nucleoside-diphosphate kinase -
GALLO_RS07490 1516449..1516829 - 381 WP_012962171.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GALLO_RS07495 1516841..1517029 - 189 WP_009854536.1 type II toxin-antitoxin system HicA family toxin Toxin
GALLO_RS07500 1517125..1517790 - 666 WP_012962172.1 type II-A CRISPR-associated protein Csn2 -
GALLO_RS07505 1517777..1518121 - 345 WP_009854538.1 CRISPR-associated endonuclease Cas2 -
GALLO_RS07510 1518118..1518984 - 867 WP_012962173.1 type II CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-108)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6837.25 Da        Isoelectric Point: 10.8207

>T24540 WP_009854536.1 NC_013798:c1517029-1516841 [Streptococcus gallolyticus UCN34]
VPLTGRELAKLAVLKGWKEVRVKGSHHQFKKDGVPYILTIPIHGNKVLGVGLEKKILKDIGL

Download         Length: 189 bp

>T24540 NC_013798:c1517029-1516841 [Streptococcus gallolyticus UCN34]
GTGCCGTTAACAGGCAGAGAGTTAGCAAAACTTGCTGTGTTAAAAGGTTGGAAAGAAGTTCGTGTAAAGGGAAGTCATCA
TCAGTTCAAAAAGGATGGCGTACCCTATATTCTTACAATTCCAATTCATGGCAACAAGGTGTTAGGTGTAGGTTTGGAAA
AGAAAATTTTAAAAGACATAGGGCTATAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14082.98 Da        Isoelectric Point: 4.2962

>AT24540 WP_012962171.1 NC_013798:c1516829-1516449 [Streptococcus gallolyticus UCN34]
MLKSYPAIFHKEGDGSFWVEFPGFGGGTEGDDVEEAMKNAREMLESSLAAYLDEGLELPKVVNMSELSVEDGFITLIQAD
PSPYLKSTKAIRKNVTVPEWLVRLADRENVNYSEVLTQALEKKLQL

Download         Length: 381 bp

>AT24540 NC_013798:c1516829-1516449 [Streptococcus gallolyticus UCN34]
ATGTTAAAATCATATCCAGCAATTTTTCACAAAGAAGGCGATGGAAGTTTTTGGGTAGAATTTCCAGGATTTGGTGGTGG
TACCGAAGGTGATGATGTCGAAGAAGCGATGAAAAATGCTCGAGAAATGTTAGAAAGCTCATTGGCTGCTTATCTAGATG
AAGGTTTAGAGCTTCCAAAGGTTGTTAATATGAGTGAATTATCAGTTGAAGATGGTTTTATCACTTTAATTCAAGCAGAC
CCTTCCCCATATTTAAAAAGTACCAAAGCCATTCGAAAAAATGTTACTGTTCCAGAATGGTTAGTCAGATTAGCAGACCG
TGAGAATGTGAATTACTCGGAGGTTTTGACACAAGCTTTAGAGAAAAAATTACAGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WDX8

Antitoxin

Source ID Structure
AlphaFold DB F5WVI9

References