Detailed information of TA system TA024539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/YoeB-RelB
• Location: 1140384..1140900
• Replicon: chromosome
• Accession: NC_013798
• Organism: Streptococcus gallolyticus UCN34

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: -
• Locus tag: GALLO_RS05660
• Protein ID: WP_012961965.1
• Coordinates: 1140384..1140641 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: F5X0X4
• Locus tag: GALLO_RS05665
• Protein ID: WP_012961966.1
• Coordinates: 1140634..1140900 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GALLO_RS05635	1135869..1136477	+	609	WP_009854174.1	TipC family immunity protein	-
GALLO_RS05640	1136660..1137508	-	849	WP_012961961.1	MurR/RpiR family transcriptional regulator	-
GALLO_RS05645	1137678..1138661	+	984	WP_012961962.1	Gfo/Idh/MocA family oxidoreductase	-
GALLO_RS05650	1138666..1139190	+	525	WP_012961963.1	heme-binding protein	-
GALLO_RS05655	1139211..1140269	+	1059	WP_012961964.1	Gfo/Idh/MocA family oxidoreductase	-
GALLO_RS05660	1140384..1140641	-	258	WP_012961965.1	Txe/YoeB family addiction module toxin	Toxin
GALLO_RS05665	1140634..1140900	-	267	WP_012961966.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GALLO_RS05670	1141064..1141396	+	333	WP_009854181.1	putative DNA-binding protein	-
GALLO_RS05675	1141467..1143032	+	1566	WP_012961967.1	signal recognition particle protein	-
GALLO_RS05680	1143098..1144114	-	1017	WP_012961968.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10281.63 Da
• Isoelectric Point: 8.7825

>T24539 WP_012961965.1 NC_013798:c1140641-1140384 [Streptococcus gallolyticus UCN34]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKTEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY

Nucleotide

• Length: 258 bp

>T24539 NC_013798:c1140641-1140384 [Streptococcus gallolyticus UCN34]
ATGATTAAAGCATGGTCTGACGATGCGTGGAACGACTACATGTATTGGTATAATCAAGGAAATAAAGCGACAATTAAAAA
AATTAATCGCCTAATCAAGGAGATTGACCGCACTCCTTTTACTGGCATTGGTAAAACTGAACCGCTTAAACACGATTTAT
CTGGCAAATGGTCACGACGTATAACCGATGAACATCGTTTAATTTACAGTGTTGATGAGACTACTATTTACTTTTATTCT
TGCAAAGACCATTATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10365.60 Da
• Isoelectric Point: 4.6290

>AT24539 WP_012961966.1 NC_013798:c1140900-1140634 [Streptococcus gallolyticus UCN34]
MEAVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD

Nucleotide

• Length: 267 bp

>AT24539 NC_013798:c1140900-1140634 [Streptococcus gallolyticus UCN34]
ATGGAAGCTGTTGCATATTCAAATTTTAGACAAAATTTAAAACATTATATGAAACAAGTTAATGATGACGCTGAACCACT
TATTGTAACTTCTAAAAATATTGATGATACTGTCGTAGTCCTTTCAAAACGTGACTATGATAGCATGCAAGAAACATTTC
GCATTATGTCTAATAACTACCTAATGAATAAAATTAAACGCGGCGATGAACAATTCAAAGCAGCTAATTTTCAGACACAT
GAATTGCTCGAGGTAGATGATGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S5WCN9