Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4806620..4807136 Replicon chromosome
Accession NZ_CP097411
Organism Klebsiella pneumoniae strain K165-2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M8Y69_RS23425 Protein ID WP_004178374.1
Coordinates 4806620..4806904 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag M8Y69_RS23430 Protein ID WP_032434351.1
Coordinates 4806894..4807136 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y69_RS23400 (4802103) 4802103..4802366 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M8Y69_RS23405 (4802496) 4802496..4802669 + 174 WP_032414379.1 hypothetical protein -
M8Y69_RS23410 (4802672) 4802672..4803415 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M8Y69_RS23415 (4803772) 4803772..4805910 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M8Y69_RS23420 (4806152) 4806152..4806616 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M8Y69_RS23425 (4806620) 4806620..4806904 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8Y69_RS23430 (4806894) 4806894..4807136 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M8Y69_RS23435 (4807214) 4807214..4809124 - 1911 WP_004152270.1 PRD domain-containing protein -
M8Y69_RS23440 (4809147) 4809147..4810301 - 1155 WP_002886900.1 lactonase family protein -
M8Y69_RS23445 (4810367) 4810367..4811107 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T245388 WP_004178374.1 NZ_CP097411:c4806904-4806620 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT245388 WP_032434351.1 NZ_CP097411:c4807136-4806894 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References