Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4713892..4714595 Replicon chromosome
Accession NZ_CP097411
Organism Klebsiella pneumoniae strain K165-2

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M8Y69_RS23035 Protein ID WP_071994632.1
Coordinates 4713892..4714233 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M8Y69_RS23040 Protein ID WP_032434296.1
Coordinates 4714254..4714595 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y69_RS23025 (4710207) 4710207..4711076 + 870 WP_023317468.1 HNH endonuclease -
M8Y69_RS23030 (4711667) 4711667..4713700 + 2034 WP_050598589.1 hypothetical protein -
M8Y69_RS23035 (4713892) 4713892..4714233 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M8Y69_RS23040 (4714254) 4714254..4714595 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M8Y69_RS23045 (4714606) 4714606..4715148 - 543 WP_032434298.1 DNA repair protein RadC -
M8Y69_RS23050 (4715161) 4715161..4715601 - 441 WP_032434300.1 antirestriction protein -
M8Y69_RS23055 (4715632) 4715632..4716453 - 822 WP_032434301.1 DUF932 domain-containing protein -
M8Y69_RS23060 (4716573) 4716573..4717046 - 474 WP_032434303.1 hypothetical protein -
M8Y69_RS23065 (4717118) 4717118..4717570 - 453 WP_032410767.1 hypothetical protein -
M8Y69_RS23070 (4717606) 4717606..4718322 - 717 WP_032434305.1 WYL domain-containing protein -
M8Y69_RS23075 (4718566) 4718566..4719440 - 875 Protein_4528 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4702189..4747862 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T245387 WP_071994632.1 NZ_CP097411:c4714233-4713892 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT245387 WP_032434296.1 NZ_CP097411:c4714595-4714254 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References