Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 22772..23511 Replicon plasmid pKPTCM-4
Accession NZ_CP097389
Organism Klebsiella pneumoniae strain KPTCM

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag M6G79_RS27340 Protein ID WP_013087269.1
Coordinates 23026..23511 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag M6G79_RS27335 Protein ID WP_007869691.1
Coordinates 22772..23038 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G79_RS27305 (M6G79_27285) 17824..18180 + 357 WP_004199403.1 hypothetical protein -
M6G79_RS27310 (M6G79_27290) 18214..18918 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
M6G79_RS27315 (M6G79_27295) 18973..19497 - 525 Protein_26 NAD(P)-dependent oxidoreductase -
M6G79_RS27320 (M6G79_27300) 19759..20520 + 762 WP_002210513.1 DeoR/GlpR family DNA-binding transcription regulator -
M6G79_RS27325 (M6G79_27305) 20541..21401 - 861 WP_002904004.1 extended-spectrum class A beta-lactamase SHV-12 -
M6G79_RS27330 (M6G79_27310) 21538..22242 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
M6G79_RS27335 (M6G79_27315) 22772..23038 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
M6G79_RS27340 (M6G79_27320) 23026..23511 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
M6G79_RS27345 (M6G79_27325) 23708..25111 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
M6G79_RS27350 (M6G79_27330) 25140..25772 - 633 WP_001567369.1 hypothetical protein -
M6G79_RS27355 (M6G79_27335) 26162..26980 - 819 WP_013087268.1 abortive infection family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaSHV-12 / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 - 1..50463 50463
- inside IScluster/Tn blaSHV-12 - 16260..25111 8851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T245375 WP_013087269.1 NZ_CP097389:23026-23511 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT245375 WP_007869691.1 NZ_CP097389:22772-23038 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References