Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4717099..4718687 Replicon chromosome
Accession NZ_CP097385
Organism Klebsiella pneumoniae strain KPTCM

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M6G79_RS22585 Protein ID WP_004179815.1
Coordinates 4717099..4718421 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M6G79_RS22590 Protein ID WP_004176198.1
Coordinates 4718421..4718687 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G79_RS22570 (4712155) 4712155..4714656 + 2502 WP_020323802.1 fimbria/pilus outer membrane usher protein -
M6G79_RS22575 (4714644) 4714644..4715648 + 1005 WP_004179822.1 fimbrial protein -
M6G79_RS22580 (4715790) 4715790..4717082 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M6G79_RS22585 (4717099) 4717099..4718421 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
M6G79_RS22590 (4718421) 4718421..4718687 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M6G79_RS22595 (4718953) 4718953..4719279 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M6G79_RS22600 (4719276) 4719276..4719776 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M6G79_RS22605 (4719754) 4719754..4721133 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
M6G79_RS22610 (4721479) 4721479..4722633 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M6G79_RS22615 (4722614) 4722614..4723537 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 4509326..4753522 244196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T245369 WP_004179815.1 NZ_CP097385:c4718421-4717099 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT245369 WP_004176198.1 NZ_CP097385:c4718687-4718421 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References