Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1881791..1882416 Replicon chromosome
Accession NZ_CP097385
Organism Klebsiella pneumoniae strain KPTCM

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag M6G79_RS08865 Protein ID WP_002882817.1
Coordinates 1881791..1882174 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M6G79_RS08870 Protein ID WP_004150355.1
Coordinates 1882174..1882416 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G79_RS08850 (1879157) 1879157..1880059 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
M6G79_RS08855 (1880056) 1880056..1880691 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M6G79_RS08860 (1880688) 1880688..1881617 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M6G79_RS08865 (1881791) 1881791..1882174 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
M6G79_RS08870 (1882174) 1882174..1882416 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M6G79_RS08875 (1882621) 1882621..1883538 + 918 WP_004181612.1 alpha/beta hydrolase -
M6G79_RS08880 (1883552) 1883552..1884493 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M6G79_RS08885 (1884538) 1884538..1884975 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M6G79_RS08890 (1884972) 1884972..1885832 - 861 WP_004146232.1 virulence factor BrkB family protein -
M6G79_RS08895 (1885826) 1885826..1886425 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T245361 WP_002882817.1 NZ_CP097385:c1882174-1881791 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT245361 WP_004150355.1 NZ_CP097385:c1882416-1882174 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References